GENE FREQUENCIES OF METHYLMALONIC ACIDEMIA DISEASE AT THE GLOBAL LEVEL AND COMPILING THE PATHOGENIC MUTATIONS IN THE IRANIAN POPULATION

Gene Frequencies of Methylmalonic Acidemia Disease at the Global Level and Compiling the Pathogenic Mutations in the Iranian Population

Background: Methylmalonic acidemia (MMA) is a rare autosomal recessive metabolic disorder resulting from a genetic defect in methylmalonyl-CoA mutase (MCM) or a defect in the biosynthesis of its cofactor, adenosyl-cobalamin (AdoCbl).The disease is caused by a mutation in six main genes (MUT, MMAA, MMAB, MMADHC, MMACHC, and MCEE).In this investigati

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Frivolous Claims: Concept and Strategies to Reduce (A Comparative Study of the Case Law of Iran and the US Law)

Fictitious litigation that is often biased by the plaintiff (whether principal, counterpart, entry or third party, or in the form of objections and complaints), includes any claim at the initial stage or even at the stages of the appeal (retrial, third party appeal and appeal), the purpose of which is to harass the other party, delay the process of

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